The Miami Dolphins vs Buffalo Bills’ total of 53.5 is the highest over/under. The smallest favorites are the Tennessee Titans by one point over the Cincinnati Bengals. The San Francisco 49ers are Week 3’s biggest opening favorites at 14 points over the Arizona Cardinals. ![]() Speaking of traveling, the Falcons and Jacksonville Jaguars will head overseas to play Sunday in the first of two NFL games in London this season. The Seattle Seahawks will travel to face the New York Giants on Monday Night Football. The Sunday Night Football matchup has the New York Jets hosting the Kansas City Chiefs. The Packers rallied from 17 points down to beat the New Orleans Saints 18-17 on Sunday while the Lions defeated the Atlanta Falcons 20-6. The Packers are 1.5-point favorites on the opening line in the NFL odds. NFL Week 4 begins when the Detroit Lions visit the Green Bay Packers on Thursday Night Football. A look at the opening NFL Week 4 odds can be found below with early predictions.The 49ers are the biggest favorites at 14 points over the Cardinals.NFL Week 4 begins with the Packers hosting the Lions on Thursday Night Football.Mandatory Credit: Cary Edmondson-USA TODAY Sports Santa Clara, California, USA San Francisco 49ers running back Christian McCaffrey (23) runs the ball against the New York Giants in the second quarter at Levi's Stadium.
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